Jumat, 11 Januari 2013

[H653.Ebook] Download Ebook Ghosts of Tsavo : Stalking the Mystery Lions of East Africa, by Phillip Caputo

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Ghosts of Tsavo : Stalking the Mystery Lions of East Africa, by Phillip Caputo

1898, Tsavo River Kenya, the British Empire has employed 140 workers to build a railroad bridge. The bridge's construction comes to a violent halt when two maneless lions devour all 140 workers in a savage feeding frenzy that would make headlines›and history—all over the world. Caputo's Ghosts of Tsavo is a new quest for truth about the origins of these near-mythical animals and how they became predators of human flesh.

  • Sales Rank: #895920 in Books
  • Brand: Brand: National Geographic
  • Published on: 2003-06-01
  • Released on: 2003-06-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.95" h x .76" w x 6.00" l, .90 pounds
  • Binding: Paperback
  • 288 pages
Features
  • Used Book in Good Condition

From Library Journal
In 1898, two maneless male lions killed and devoured 135 Indian and African workers constructing a railroad bridge over the Tsavo River in Kenya. It took Lt. Col. John Henry Patterson, the engineer in charge of the project, nine months to hunt and kill the beasts, an ordeal recounted in his 1907 book, The Man-Eaters of Tsavo, and later the subject of two films, 1952's Bwana Devil and 1996's The Ghost and the Darkness. A century later, the story of Ghost and Darkness still fascinates and terrifies. Were they just rogue lions, or were they the "missing genetic link" between the prehistoric cave cats who hunted early humans and the modern African lion? Novelist Caputo (The Voyage) seeks answers to this intriguing question as he accompanies two separate expeditions to study the maneless lions of Tsavo. Unfortunately, the resulting book is a frustrating mix of personal travel narrative and scientific speculation, with no definite conclusions. Admitting his ambivalence, Caputo writes: "I feel divided, half of me hungry for scientific truth, the other half seeking to embrace the mythic. It occurs to me that I haven't come close to solving the mystery of Tsavo's lions, probably because my heart hasn't been in it." Still, Caputo's muscular prose vividly captures the beauty and dangers of Africa, and there will be demand because of his name. For larger adventure and natural history collections. Wilda Williams, "Library Journal"
Copyright 2002 Cahners Business Information, Inc.

From Booklist
Caputo is a superb yarn-spinner with a love of adventure and a penchant for philosophizing. A best-selling, Pulitzer Prize-winning novelist, memoirist, and journalist, he's really been around--"at last count, I've lived, worked, traveled, and fought and covered wars in 48 countries on 4 continents"--so it's no surprise to find that Caputo's latest compelling work of nonfiction chronicles a quest on foreign ground. The inspiration for Caputo's African sojourn is found in the Field Museum of Natural History in Chicago, the final resting place for the two infamous, maneless, man-eating male lions of Tsavo, an inhospitable and scrubby coastal region in East Africa. These beasts "attained mythic status" by killing and eating 135 railway laborers in 1898, and their cunning descendants continue to take humans as prey and to intrigue scientists who want to know why some lions hunt human beings, why most male lions have manes, and why many male Tsavo lions do not. Caputo relishes hair-raising tales of man-eaters and explicates various theories about them, while entertainingly chronicling his experiences as part of a photography and research safari in Kenya's wildlife reserve. Not only does he excel at evoking the beauty of his surroundings and describing his own sometimes harrowing encounters with wildlife, he also reflects cogently on the consequences of our precipitous decimation of the wild. It turns out that there's nothing all that mysterious about the Tsavo lions: they simply hunt to live. It's our unnecessarily violent species that remains obdurately enigmatic. Donna Seaman
Copyright © American Library Association. All rights reserved

Review
"A sprightly and informative travel adventure."

"Caputo gives us Africa in all of its parched and scrubby beauty, a land raw and primitive, inhabited by jakals and hyenas, acacia trees and watering holes--and, of course, lions that occasionally prey on homo sapiens."

"Ghosts of Tsavo makes for great summer reading."

Most helpful customer reviews

27 of 27 people found the following review helpful.
Engaging look at unusual lions
By Amazon Customer
"Ghosts of Tsavo" is part travelogue, part natural history, part murder mystery, and part mid-life crisis for its author Philip Caputo. What it is as a whole is a fascinating, engaging look at the lions of Tsavo Park in Kenya. Caputo first became interested in these unusual lions as a result of a visit to the Field Museum in Chicago as a young boy. Therein were "Ghost" and "Darkness" two enormous males lions that terrorized constructions workers building a rail line through Tsavo. In fact terrorized may be too weak a word as they are credited with killing at least 120 people and literarily halting construction until they were eventually hunted down and killed by British Lt. Col. Patterson who was heading up the project. He recounted this effort in his famous memoir "The Man Eaters of Tsavo" and kindled a fascination with Kenya's lions that lingered with Caputo for half a century.

What sets the lions of Tsavo apart from the more familiar ones we know from nature documentaries, is that they are much bigger, and the males are either maneless of have very short manes, in either case nothing like the regal mountains of fur on their cousins from the Serengeti. In the first half of the book, Caputo explores reasons as to why this might by the case. It is possible that since Tsavo is much warmer than the Serengeti, manes are too expensive in terms of internal resources to grow. Another possibility is that the thick scrub brush and thorns of the region wear down manes before they ever become truly impressive.

However, it is a more controversial theory that makes for the most entertaining reading. Caputo encounters several scientists who argue that the lions of Tsavo are genetically distinct from the lions on the Serengeti. Moreover, they argue that the lions of Tsavo are in fact a throw back to prehistoric lions, quite literally walking fossils. The point to the lack of manes, the much larger height and girth and the fact that Tsavo lions hunt the enormous Cape Buffalo as justifications for this thesis.

Ultimately, Caputo, in three journeys to Kenya over the course of eighteen months (once as a tourist and twice with scientific expeditions) is never able to definitively state which hypothesis is correct. However, that in no way detracts from his rambling, conversational narrative. Caputo is not a scientist, and he in no way pretends to be one, although he does (and justifiably so) consider himself a well-informed observer. As such, he is not constrained by the rigors of academia, and can therefore transfer his passion for these lions and the mystery surrounding them onto the page. In fact, towards the end he grows weary of the scientific studies as they somehow detract from the powerful aura that surrounds the lions.

If you are interested in lions in general, or if the prospect of some spine-tingling tales of man-eating lions sounds appealing, "Ghost of Tsavo" is well worth reading. However, beyond the surface elements, Caputo has written a book that captures the raw spirituality of nature, and that bemoans modern man's detachment from the primitive. So it is entirely likely that even if you have no interest in lions at all, you may be drawn to Caputo's lament for something we don't even realize we have lost. Either way, "Ghost's of Tsavo" is well worth reading.

Jake Mohlman

18 of 18 people found the following review helpful.
Confronting the nightmare lions and oneself.
By Mary Whipple
Long fascinated with the subject of man-eating lions, Philip Caputo does not pretend to be an expert on them, the environment, or African affairs. In fact, his lack of expertise and his desire to learn give this book some of its appeal and make it totally accessible, even to the most scientifically challenged reader. Consulting experts from Chicago's Field Museum and from the University of Minnesota, before, during, and after two trips he makes to Kenya's Tsavo National Park, Caputo immerses himself in their research, familiarizing the reader, in the process, with the lions, their behavior, and their controversies.

Far more apt to attack and eat humans than are the Serengeti plains lions, the man-eaters of Tsavo are giants, much longer from nose to tail, much taller at the shoulder, and 100 - 150 pounds heavier than the plains lions, and the males are often maneless. Caputo's experts strongly disagree on whether these giant lions differ simply because they have adapted to the hotter climate of Tsavo and their need to kill Cape buffalo for food, or whether, in fact, they represent a missing link between modern lions and the maneless cave lions of the Pleistocene era, which roamed throughout the Near East and Africa.

Stories of famous man-eaters of the past hundred years, including two which killed 135 people in 1898, and one 550-pounder from 1991, add drama and excitement to the narrative. But Caputo also ranges widely into peripheral, more personal subjects--why he believes hunters are closer to nature than are photographers, why tracking a lion on foot for four days is a more divine experience than using a vehicle, evolution vs. creationism, cloning, science vs. faith, and even his nightmares. Ultimately, the book is as much about Caputo as about the lions, who remain a mystery. "The truth is," he concludes, "I don't want to learn anything more about lions, but am content...to keep some blank spots blank; after all, those are what excite the imagination." Mary Whipple

11 of 13 people found the following review helpful.
Well done, both exciting and balanced.
By Sore back
Watch for The Ghosts of Tsavo to find a well-deserved spot on the best-seller lists. Caputo blends one bit travelogue with a splash of John McPhee, frappes it with some exciting writing, then serves it over the rocks of some hard scientific facts. This is a yarn, but a great one. The prologue is, hands down, the best story of someone hunting a man eating lion I have ever read. But this is not the "Jaguars Clawed My Flesh" school of big cat writing. His is a journey of exploration of the old school, similar to an expedition in the 19th Century from the Field Museum, which inspired Caputo as a child. Scientists will be happy to see he balances all of this with reason. Romantics will be happy to see he balances science with emotion. He has a gift, too, of beginning a personal rant on a point of politics and philosphy, and then doubling back on himself and to laugh at himself. He explores myths and explodes myths. Yet there is a romantic side to him that values them and the unknown. A good read, good reporting. Buy it, if the theme appeals to you at all, or if you ever looked up, as Caputo did as a child, at the great stuffed cats in museums.

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Kamis, 10 Januari 2013

[C801.Ebook] Ebook Download Jurisdiction in International Law (Oxford Monographs in International Law), by Cedric Ryngaert

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Jurisdiction in International Law (Oxford Monographs in International Law), by Cedric Ryngaert

This fully updated second edition of Jurisdiction in International Law examines the international law of jurisdiction, focusing on the areas of law where jurisdiction is most contentious: criminal, antitrust, securities, discovery, and international humanitarian and human rights law. Since F.A. Mann's work in the 1980s, no analytical overview has been attempted of this crucial topic in international law: prescribing the admissible geographical reach of a State's laws.

This new edition includes new material on personal jurisdiction in the U.S., extraterritorial applications of human rights treaties, discussions on cyberspace, the Morrison case. Jurisdiction in International Law has been updated covering developments in sanction and tax laws, and includes further exploration on transnational tort litigation and universal civil jurisdiction.

The need for such an overview has grown more pressing in recent years as the traditional framework of the law of jurisdiction, grounded in the principles of sovereignty and territoriality, has been undermined by piecemeal developments. Antitrust jurisdiction is heading in new directions, influenced by law and economics approaches; new EC rules are reshaping jurisdiction in securities law; the U.S. is arguably overreaching in the field of corporate governance law; and the universality principle has gained ground in European criminal law and U.S. tort law.

Such developments have given rise to conflicts over competency that struggle to be resolved within traditional jurisdiction theory. This study proposes an innovative approach that departs from the classical solutions and advocates a general principle of international subsidiary jurisdiction. Under the new proposed rule, States would be entitled, and at times even obliged, to exercise subsidiary jurisdiction over internationally relevant situations in the interest of the international community if the State having primary jurisdiction fails to assume its responsibility.

  • Sales Rank: #1825721 in Books
  • Published on: 2015-06-16
  • Original language: English
  • Number of items: 1
  • Dimensions: 6.30" h x .80" w x 9.30" l, .22 pounds
  • Binding: Hardcover
  • 272 pages

Review
Review from previous edition: "This ambitious book, based on Cedric Ryngaert's PhD at Leuven University, does not disappoint. Its aim is nothing less than a comprehensive analysis of the admissible geographical reach of State legislative power...this remarkably concise volume is a gem bound to become a reference on prescriptive jurisdiction in International law" --Michael Waibel, ICLQ, Vol 58 October 2009

"...a welcome and timely piece of scholarship, especially as a comprehensive examination of State jurisdiction appears to have been previously attempted over two decades ago...The book at hand doubtlessly succeeds in challenging the reader's views about the way in which international law deals with the exercise of state jurisdiction. Ryngaert's plan for revision is ambitious and thought-provoking, though not without difficulties" --Rain Liivoja, Finnish Yearbook of International Law

About the Author

Cedric Ryngaert, Professor of Public International Law, School of Law, Utrecht University

Cedric Ryngaert is Professor of Public International Law at the University of Utrecht, and Assoicate Professor at Leuven University. He holds a tenured position at both universities. He studied law at Leuven University (1996-2001), where he also obtained his PhD in 2007 (on jurisdiction in international law, under the supervision of Prof. dr. Jan Wouters). He was visiting researcher at Harvard Law School in 2005, and assistant district prosecutor in Leuven in 2006. Cedric has taught courses on public international law, the law of international organizations, and the law of armed conflicts. In 2012, he won the five-yearly Henri Rolin prize (international law and international relations) for his work on jurisdiction.

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0 of 0 people found the following review helpful.
Five Stars
By A Satisfied Customer
A satisfied customer.

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[X270.Ebook] Ebook Your Ministry and Your Ancestry, by Dr. D. K. Olukoya

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Your Ministry and Your Ancestry, by Dr. D. K. Olukoya

YOUR MIN1STRY AND YOUR ANCESTRY
The battles of life are common to all and sundry, therefore the fact that you are a minister does not erase your ancestral roots. To this end, many pastors, ministers and church leaders are ignorant of the impact ancestral factors have on the lives of men and women of Cod.
A lot of ministers who have failed in the ministry could not really understand the
reason(s) behind their failures. Some are even blinded to the fact that they have
battles to fight. These battles are deeply entrenched in the foundations of many
ministers of the gospel and if something is not done urgently, many more will die
miserably without fulfillingtheir destinies.
While the battles and challenges faced by those who are not ministers are ordinary,
the battles faced by ministers are complicated and advanced in nature.
This book exposes you to those battles, how to tackle them and it explains what
you need to do to deal with them and be permanently free from them. Be blessed
on this journey of discovery and recovery.

  • Sales Rank: #530770 in eBooks
  • Published on: 2015-11-23
  • Released on: 2015-11-23
  • Format: Kindle eBook

Most helpful customer reviews

0 of 0 people found the following review helpful.
War against ancestral powers.
By Faith in action
This book met my expectation in so many ways. To name a few, I am battling generational problems, paying for what I did not buy.
Ancestral powers and strongman in the family that do not want to let go.
This book is an eye opening for anyone who is going thru serious warfare that baffles one. There are so many prayers that really hit the nail. I thank God that I purchased this book.
Thank you Sir for helping us and our family as we are delivered. May God bless you, family and the ministry.

0 of 0 people found the following review helpful.
your ministry and your ancestry
By Sithembile
The book is an eye opener, every minister of God should, I have learnt so many things, Now by the time I am ordained I will have delt and done with whatever stronghold

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Five Stars
By E.T.
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Rabu, 09 Januari 2013

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The Meditator's Workbook: A Journey to the Center, by Matthew Flickstein

Using hands-on exercises, journal entries, guided meditations, and lively vignettes, The Meditator's Workbook will help you:

  • Live more deeply and joyfully in the moment
  • Uncover the true source of stress
  • Resolve grief
  • Explore and express forgiveness
  • See through the inevitable distortions of the mind
  • Recognize and actualize your goals
  • Find real inner peace and a thoroughgoing well-being

Whether your goal is to reduce stress or to gain deeper insight and mastery over your inner life, this simple, straightforward guidebook is the tool to use for learning why and how to meditate. Through its unique workbook-style presentation, The Meditator's Workbook leads you to discover your own starting point, teaches you how to gain mental clarity and remove the obstacles you inevitably encounter, and helps you to identify the insights that are appropriate to each stage of your journey to spiritual and psychological maturity.

  • Sales Rank: #1656646 in Books
  • Brand: Flickstein, Matthew/ Gunaratana, Bhante (FRW)
  • Published on: 2009-06-30
  • Released on: 2009-06-30
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.00" h x .60" w x 6.00" l, .75 pounds
  • Binding: Paperback
  • 210 pages

Review
"This is the kind of book that can change a person's life and point the way to peace and happiness." (Bhante Henepola Gunaratana, author of Mindfulness in Plain English and Beyond Mindfulness in Plain English)

"A book to do rather than simply to read, to be worked with slowly but also joyfully." (NAPRA ReView)

"The format makes the mediations easy to follow, simple to do, and very effective." (New Age Retailer)

"Thorough, insightful, and comprehensive." (Meditation Pathways)

About the Author
Matthew Flickstein is a psychotherapist, meditation teacher, and the founder of The Forest Way Insight Meditation Center in the Blue Ridge Mountains of Virginia. In more than twenty years of leading personal development workshops, he has trained almost 15,000 people across the US, including other teachers.

Bhante Gunaratana was ordained at the age of twelve as a Buddhist monk in Sri Lanka, earned his PhD in philosophy from The American University, and has led meditation retreats, taught Buddhism, and lectured widely throughout the United States, Canada, Europe, and Australia. Bhante Henepola Gunaratana is the president of the Bhavana Society in High View, West Virginia, where he lives.

Most helpful customer reviews

35 of 42 people found the following review helpful.
Extremely disappointing
By bda
I found this book to be very disappointing, especially since I absolutely loved this author's other book, "The Meditator's Atlas." (Which I highly recommend.)

The meditations talked about here are the same type of pop-psychology meditations that one finds in many other books. The "visualize yourself in a room talking with someone who's hurt you" type of thing.

This book recommends using Buddhist meditation to achieve your goals: Financial goals, career goals, etc. which seems to me to be the exact opposite of what Buddhism is about.

Perhaps this is a good book on meditation, but it's not a book about Buddhist meditation, except for the fact that it uses some techniques originally rooted it Buddhism.

1 of 1 people found the following review helpful.
A workbook to help tame your ox
By Alain B. Burrese
“The Meditator's Workbook: A Journey To The Center” by Matthew Flickstein is a workbook, and to get the most out of it, one should not only read it, but do the meditations and exercises provided throughout the text. Doing this book, rather than just reading it, helps live life more fully, relieve stress and grief, and find personal inner-peace and well being. Obviously, these things can be said for meditation in general, regardless the type one practices or the source one learns from. But this book focuses on assisting one with these and more through the guided practice of meditation.

The book uses the Ten Oxherding Pictures as a base for the lessons along one's journey. As Flickstein states, “the ox symbolizes your true nature, the reality that lies beyond your conditioned and transitory existence . 'Herding the wild ox' is a metaphor for the progressive stages of realization that you will encounter during your quest for enlightenment.” I'll admit, it was this ox herding focus that drew me to purchasing the book. I've always liked these pictures, and their meaning, since learning about them from a friend as we gazed upon a series of pictures on the outside of a temple in Korea.

Using the pictures as a framework to organize the lessons, Flickstein guides the reader through a journey of finding oneself through a series of meditations. Accompanying these meditations, are questions to help you think about things that will help you find peace within yourself as well as figure out where you really want to go. There are also blank pages where you are encouraged to journal about the things you are thinking and meditating about.

There are some meditations and sections of this book that might not be as relevant to all readers, and some parts that some might not think are relevant until actually meditating on and pondering the questions the author poses. Throughout all of the exercises and meditations, one can learn about the self and become more mindful, which is the beginning to “enlightenment” or self-discovery. I'm not sure if we ever really become enlightened, but I do think we can discover more about ourselves and live happier more positive lives, and doing this book can help you with that.

Recommended to all who want to look within themselves a little deeper through meditation and self-discovery. Take this journey to help tame your ox.

1 of 1 people found the following review helpful.
Meditating for Beginners
By barb
We all have to start somewhere and quieting the mind and meditating is a real challenge...This book offered lots of really helpful hints and exercises to bring me to a new lever. A must read.

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Kamis, 13 Desember 2012

[L241.Ebook] Free PDF Monster Hunter Orage 1, by Hiro Mashima

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Monster Hunter Orage 1, by Hiro Mashima

Shiki's mission is to wonder to the ends of the Earth to hunt down a terrifying monster of legends! His companion is Ailee, a skilled huntress who would rather have nothing to do with the airheaded Shiki. Now the excitement of the Monster Hunter games meets the creative genius of Fairy Tale's Hiro Mashima in a fun, thrill-filled fantasy adventure!

  • Sales Rank: #744213 in Books
  • Brand: Brand: Kodansha Comics
  • Published on: 2011-06-28
  • Released on: 2011-06-28
  • Original language: English
  • Number of items: 1
  • Dimensions: 7.50" h x .63" w x 5.00" l, .40 pounds
  • Binding: Paperback
  • 192 pages
Features
  • Used Book in Good Condition

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2 of 2 people found the following review helpful.
Very Enjoyable Series
By Jannette Emmerick
Since I bought and read all four volumes, I'll review the series as a whole:
I really loved reading Monster Hunter Orage. It was told in a very Hiro Mashima way if you're familiar with his style, this is very obviously his work. The four main characters are very lovable, and if you're looking for a quick read manga series in the world of a great game this is perfect. This is a typical shounen action manga, and even if it wasn't a deep story, I thoroughly enjoyed it. 10/10 would recommend to any Monster Hunter fan.
For me, the best part of this series were Hiro Mashima's afterward notes and the extras, especially the ones featured at the end of volume 4.

1 of 1 people found the following review helpful.
Five Stars
By Jose Romero
condition excellent, and good manga

0 of 0 people found the following review helpful.
Nice books
By bella123
My son just loves these kinds of books so he enjoys this one. Thank you, it arrived in perfect shape!

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Rabu, 12 Desember 2012

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Kaplan’s GMAT Verbal Foundations provides a back-to-basics, tutor-led approach to content review along with the skill-building practice you need to feel confident and improve your GMAT score. Best of all, unlike other English language review books, Kaplan’s GMAT Verbal Foundations covers only the specific grammar, style, and usage concepts you need to know in order to master the Verbal section of the GMAT.

  • Sales Rank: #1196091 in Books
  • Published on: 2013-05-07
  • Released on: 2013-05-07
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.00" h x .80" w x 7.00" l, 1.35 pounds
  • Binding: Paperback
  • 352 pages

About the Author
Celebrating 75+ years as the world leader in the test prep industry, Kaplan Test Prep (www.kaptest.com) is a premier provider of educational and career services for individuals, schools and businesses. With a comprehensive menu of online offerings as well as a complete array of print books and digital products, Kaplan offers preparation for more than 90 standardized tests, including entrance exams for secondary school, college and graduate school, as well as professional licensing exams for attorneys, physicians and nurses.  Kaplan also provides private tutoring and graduate admissions consulting services.
Questions about what you’re studying?
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Most helpful customer reviews

4 of 4 people found the following review helpful.
It is OK. There are better resources
By GMAT Club (Expert)
When this book originally came out, there were not great Grammar books for the GMAT and this was the best one (the only one too). It no longer is, however. If it is the only grammar resource you can find (there are some free ones), I would recommend it. However, most people would probably NOT need this book, a copy of Manhattan GMAT Sentence Correction should do it for you and esp that the MGMAT Verbal Foundations book is out (that nicely integrates with MGMAT SC, this book lost its appeal)

Foundations of GMAT Verbal (Manhattan Gmat Strategy Guide: Verbal Gmat Supplement Guide)
Sentence Correction GMAT Strategy Guide, 5th Edition (Manhattan Gmat Strategy Guide: Instructional Guide)

Hopefully this will get you started. See my reviews for all other GMAT Books.
BB - Founder of GMAT Club; GMAT 750

P.S. Let me know if you have any questions about this guide or other books - I reply to comments and appreciate any feedback (especially negative and suggestions for improvement).
Good luck on your GMAT.

0 of 0 people found the following review helpful.
Five Stars
By mary
Excellent book, explained a lot of basic information as such grammar and sentence structure very well.

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Minggu, 02 Desember 2012

[R309.Ebook] Download PDF Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and TranslationFrom Academic Press

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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.

Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.

These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.



  • Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedside
  • Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenarios
  • Categorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications

  • Sales Rank: #3338315 in eBooks
  • Published on: 2012-12-31
  • Released on: 2012-12-31
  • Format: Kindle eBook

Review

"Socié and Blazar provide clinical and scientific researchers with 12 chapters on research on allogenic hematopoietic stem cell transplantation (HSCT) and implications for translational practice."--Reference and Research Book News, August 2013 "Bruce Blazar and Gérard Socié have put together an important book on the Immune Biology of Stem Cell Transplants. The Authors chosen for specific chapters are all recognized experts in their field. This book will be very popular among young scientists in training, as well as among experienced transplanters."--Andrea Bacigalupo, MD, Head of the Department of Hematology at Ospedale San Martino in Genoa, Italy "Self/non-self discrimination is a fundamental requirement of life. Accordingly, vertebrates are equipped with an adaptive immune system that is eminently self-referential: it is selected on self-molecules, sustained by self-molecules, and activated in the presence of self-molecules. Therefore, what might be the consequences of introducing a mature immune system in a novel "non-self" host? The consequences are many. Some are predictable and dreadful (e.g., graft-vs.-host disease), other unexpected and awe-inspiring (e.g., the graft-vs.-leukemia effect). Nonetheless, when allogeneic hematopoietic stem cell transplantation was introduced in medicine, it would have been impossible to anticipate its profound impact on our understanding of immunobiology. Gérard Socié and Bruce Blazar have taken up the gauntlet. They have assembled a dream team of experts who present a clear, comprehensive, critical and exciting picture of the current knowledge in immunobiology of allogeneic hematopoietic stem cell transplantation."--Claude Perreault, PhD, Professor and Canada Research Chair in Immunobiology Institute for Research in Immunology and Cancer Université de Montréal

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